Effects of genetically determined mineral status on life expectancy: a Mendelian randomization study

In this study, we investigated the causal effects of six minerals (calcium, magnesium, iron, copper, zinc, and selenium) on life expectancy with large-scale genome-wide association study (GWAS) summary data using two-sample Mendelian randomization (MR) analysis. [3] The genetic variations related to...

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Bibliographic Details
Published inChinese medical journal Vol. 136; no. 2; pp. 242 - 244
Main Authors Fang, Hongjuan, Chen, Weiqi, Jin, Aoming, Wang, Mengxing, Yan, Hongyi, Xiang, Xianglong, Pan, Yuesong
Format Journal Article
LanguageEnglish
Published China Lippincott Williams & Wilkins Ovid Technologies 20.01.2023
Lippincott Williams & Wilkins
Wolters Kluwer
Subjects
Bone Density
Consortia
Copper
Correspondence
Gene loci
Genome-Wide Association Study
Genomes
Life Expectancy
Mendelian Randomization Analysis
Minerals
Polymorphism, Single Nucleotide
Selenium
United Kingdom > UK
Beijing China
China
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Summary:In this study, we investigated the causal effects of six minerals (calcium, magnesium, iron, copper, zinc, and selenium) on life expectancy with large-scale genome-wide association study (GWAS) summary data using two-sample Mendelian randomization (MR) analysis. [3] The genetic variations related to blood copper, zinc, and selenium concentrations were derived from Australian (the Queensland Institute of Medical Research, QIMR) and UK (the Avon Longitudinal Study of Parents and Children, ALSPAC) data. [...]findings of this MR study showed that genetically higher serum calcium, serum iron, and blood zinc concentrations may be associated with a reduced life expectancy.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:2542-5641
0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002436