The role of atrial pressure in secreting atrial natriuretic polypeptides

The role of atrial pressure and catecholamines in secreting human atrial natriuretic polypeptides (hANP) were investigated in patients with acute or old myocardial infarction (AMI or OMI). No differences were observed in hANP levels obtained from brachial vein, right atrium, pulmonary artery and fem...

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Published inThe American heart journal Vol. 113; no. 6; pp. 1457 - 1463
Main Authors Matsubara, Hiroaki, Nishikawa, Mitsushige, Umeda, Yukihisa, Taniguchi, Tomomichi, Iwasaka, Toshiji, Kurimoto, Toru, Yamane, Yoko, Inada, Mitsuo
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.06.1987
Elsevier
Subjects
Aged
Atrial Natriuretic Factor - blood
Atrial Natriuretic Factor - metabolism
Biological and medical sciences
Blood Pressure
Cardiology. Vascular system
Coronary Circulation
Coronary heart disease
Epinephrine - blood
Exercise Test
Female
Heart
Heart Atria
Hemodynamics
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - physiopathology
Norepinephrine - blood
Heart
Human
Hormone
Atrium
Infarct
Myocardium
Cardiovascular disease
Hemodynamics
Coronary heart disease
Pressure
Atrial natriuretic factor
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Summary:The role of atrial pressure and catecholamines in secreting human atrial natriuretic polypeptides (hANP) were investigated in patients with acute or old myocardial infarction (AMI or OMI). No differences were observed in hANP levels obtained from brachial vein, right atrium, pulmonary artery and femoral artery, suggesting that hANP degradation in the pulmonary circulation has little clinical significance in hANP measurement. Plasma hANP levels in 10 patients with AMI were higher than those in controls and significantly correlated to both mean right atrial pressure (mRA) and pulmonary wedge pressure (PCW) (r = 0.76, p < 0.05; r = 0.95; p < 0.01, respectively). In 12 patients with OMI, plasma hANP levels were normal at rest and were significantly increased (p < 0.01) with bicycle ergometer exercise associated with significant elevations of plasma catecholamine levels, mRA, and PCW. However, the increments of hANP correlated only to those of PCW. These results suggest that the elevation of atrial (principally left atrial) pressure rather than catecholamine stimulates hANP secretion.
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ISSN:0002-8703
1097-6744
DOI:10.1016/0002-8703(87)90662-4