Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation

• Published in: American journal of transplantation Vol. 23; no. 8; pp. 1209 - 1220
• Main Authors: Cron, David C., Husain, Syed A., King, Kristen L., Mohan, Sumit, Adler, Joel T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: allocation policy; broader distribution organ offer; concentric circle; Humans; Kidney; kidney allocation system; kidney offer; kidney transplant; Kidney Transplantation; Tissue and Organ Procurement; Tissue Donors; transplant center; Transplants; Waiting Lists; KAS250; United States; kidney transplant; kidney allocation system; IQR; kidney offer; broader distribution organ offer; OPO; COVID-19; KDPI; allocation policy; DSA; KDRI; DDKT; transplant center; SRTR; concentric circle
• ISSN: 1600-6135; 1600-6143; 1600-6143
• DOI: 10.1016/j.ajt.2023.05.005

The newest kidney allocation policy kidney allocation system 250 (KAS250) broadened geographic distribution while increasing allocation system complexity. We studied the volume of kidney offers received by transplant centers and the efficiency of kidney placement since KAS250. We identified deceased-donor kidney offers (N = 907,848; N = 36,226 donors) to 185 US transplant centers from January 1, 2019, to December 31, 2021 (policy implemented March 15, 2021). Each unique donor offered to a center was considered a single offer. We compared the monthly volume of offers received by centers and the number of centers offered before the first acceptance using an interrupted time series approach (pre-/post-KAS250). Post-KAS250, transplant centers received more kidney offers (level change: 32.5 offers/center/mo, P < .001; slope change: 3.9 offers/center/mo, P = .003). The median monthly offer volume post-/pre-KAS250 was 195 (interquartile range 137-253) vs. 115 (76-151). There was no significant increase in deceased-donor transplant volume at the center level after KAS250, and center-specific changes in offer volume did not correlate with changes in transplant volume (r = −0.001). Post-KAS250, the number of centers to whom a kidney was offered before acceptance increased significantly (level change: 1.7 centers/donor, P < .001; slope change: 0.1 centers/donor/mo, P = .014). These findings demonstrate the logistical burden of broader organ sharing, and future allocation policy changes will need to balance equity in transplant access with the operational efficiency of the allocation system.