Gastric lesions produced by conditioned emotional stimuli in the form of affective communication and effects of benzodiazepines

• Published in: Life sciences (1973) Vol. 34; no. 2; p. 187
• Main Authors: Ichimaru, Y, Moriyama, M, Gomita, Y
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.1984
• Subjects: Animals; Anti-Anxiety Agents; Benzodiazepines - pharmacology; Benzodiazepines - therapeutic use; Benzodiazepinones - pharmacology; Diazepam - pharmacology; Electroshock; Emotions - drug effects; Gastric Mucosa - pathology; Humans; Male; Mice; Mice, Inbred Strains; Stomach - physiopathology; Stomach Ulcer - drug therapy; Stomach Ulcer - etiology; Stomach Ulcer - pathology
• ISSN: 0024-3205
• DOI: 10.1016/0024-3205(84)90589-7

Formation of gastric lesions in response to conditioned emotional stimulus (CES) and effects of benzodiazepines were studied in mice. The CES was introduced in the form of affective communication through a communication box. The "senders" were exposed to electric foot shock and the "responders" were able to receive affective cues such as visual, auditory and olfactory from "senders". The "senders" and "responders" exhibited significantly greater gastric lesions than the controls. Diazepam at doses of 2 X 1 - 2 mg/kg (p.o.) and oxazolam at a dose of 2 X 2 mg/kg (p.o.), reduced the formation of gastric lesions of the "responders" induced non-physically by CES. The present results indicate that "responders" showed bodily changes under CES treatment, particularly in the development of gastric lesions, and that gastric lesions produced by CES were protected by diazepam and oxazolam.