GABA (A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6/IL-12 production
Abstract The expression and functionality of the gamma aminobutyric acid A receptor (GABAA R) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain Reaction showed that macrophages express the GABAA R RNA for the α1, α2, β3 and δ subunits, but not for the α5, β1, β2 and γ3 subunit...
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| Published in | Journal of neuroimmunology Vol. 188; no. 1; pp. 64 - 68 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
01.08.2007
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| Abstract | Abstract The expression and functionality of the gamma aminobutyric acid A receptor (GABAA R) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain Reaction showed that macrophages express the GABAA R RNA for the α1, α2, β3 and δ subunits, but not for the α5, β1, β2 and γ3 subunits. The expression of α1 subunit was also revealed by confocal microscopy. LPS-stimulated macrophages significantly reduced their in vitro production of IL-6 and IL-12 after GABA adding to the culture medium. These results showed that BALB/c mice peritoneal macrophages express a functional subset of GABAA R subunits. |
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| AbstractList | The expression and functionality of the gamma aminobutyric acid A receptor (GABA
AR) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain Reaction showed that macrophages express the GABA
AR RNA for the α1, α2, β3 and δ subunits, but not for the α5, β1, β2 and γ3 subunits. The expression of α1 subunit was also revealed by confocal microscopy. LPS-stimulated macrophages significantly reduced their
in vitro production of IL-6 and IL-12 after GABA adding to the culture medium. These results showed that BALB/c mice peritoneal macrophages express a functional subset of GABA
AR subunits. Abstract The expression and functionality of the gamma aminobutyric acid A receptor (GABAA R) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain Reaction showed that macrophages express the GABAA R RNA for the α1, α2, β3 and δ subunits, but not for the α5, β1, β2 and γ3 subunits. The expression of α1 subunit was also revealed by confocal microscopy. LPS-stimulated macrophages significantly reduced their in vitro production of IL-6 and IL-12 after GABA adding to the culture medium. These results showed that BALB/c mice peritoneal macrophages express a functional subset of GABAA R subunits. The expression and functionality of the gamma aminobutyric acid A receptor (GABA sub(A)R) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain Reaction showed that macrophages express the GABA sub(A)R RNA for the alpha 1, alpha 2, beta 3 and delta subunits, but not for the alpha 5, beta 1, beta 2 and gamma 3 subunits. The expression of alpha 1 subunit was also revealed by confocal microscopy. LPS-stimulated macrophages significantly reduced their in vitro production of IL-6 and IL-12 after GABA adding to the culture medium. These results showed that BALB/c mice peritoneal macrophages express a functional subset of GABA sub(A)R subunits. The expression and functionality of the gamma aminobutyric acid A receptor (GABA(A)R) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain Reaction showed that macrophages express the GABA(A)R RNA for the alpha1, alpha2, beta3 and delta subunits, but not for the alpha5, beta1, beta2 and gamma3 subunits. The expression of alpha1 subunit was also revealed by confocal microscopy. LPS-stimulated macrophages significantly reduced their in vitro production of IL-6 and IL-12 after GABA adding to the culture medium. These results showed that BALB/c mice peritoneal macrophages express a functional subset of GABA(A)R subunits. |
| Author | García-Tamayo, Fernando Hernández-Hernández, Francisca Reyes-García, Maria Guadalupe Hernández-Téllez, Beatriz |
| Author_xml | – sequence: 1 fullname: Reyes-García, Maria Guadalupe – sequence: 2 fullname: Hernández-Hernández, Francisca – sequence: 3 fullname: Hernández-Téllez, Beatriz – sequence: 4 fullname: García-Tamayo, Fernando |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17599468$$D View this record in MEDLINE/PubMed |
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| Snippet | Abstract The expression and functionality of the gamma aminobutyric acid A receptor (GABAA R) in mice macrophages was explored. Reverse... The expression and functionality of the gamma aminobutyric acid A receptor (GABA AR) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain... The expression and functionality of the gamma aminobutyric acid A receptor (GABA(A)R) in mice macrophages was explored. Reverse Transcriptase-Polymerase Chain... The expression and functionality of the gamma aminobutyric acid A receptor (GABA sub(A)R) in mice macrophages was explored. Reverse Transcriptase-Polymerase... |
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| SubjectTerms | Allergy and Immunology Analysis of Variance Animals Dose-Response Relationship, Drug Drug Interactions GABA GABA A receptor GABA Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism IL-12 IL-6 Interleukin-12 - metabolism Interleukin-6 - metabolism Macrophages Macrophages - metabolism Male Mice Mice, Inbred BALB C Neurology Peritoneum - cytology Picrotoxin - pharmacology Protein Subunits - genetics Receptors, GABA-A - genetics Receptors, GABA-A - metabolism RNA, Messenger - metabolism RNA, Messenger - physiology RT-PCR |
| Title | GABA (A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6/IL-12 production |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0165572807001750 https://dx.doi.org/10.1016/j.jneuroim.2007.05.013 https://www.ncbi.nlm.nih.gov/pubmed/17599468 https://search.proquest.com/docview/19679636 |
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