Expression and Prognostic Value of IFIT1 and IFITM3 in Head and Neck Squamous Cell Carcinoma

Abstract Objectives Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) and interferon-induced transmembrane protein 3 (IFITM3) are commonly induced by type I interferon. The study aims to investigate the expression and clinical significance of IFIT1 and IFITM3 in head and neck squam...

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Published inAmerican journal of clinical pathology Vol. 153; no. 5; pp. 618 - 629
Main Authors Li, Hao, Yang, Lei-Lei, Wu, Cong-Cong, Xiao, Yao, Mao, Liang, Chen, Lei, Zhang, Wen-Feng, Sun, Zhi-Jun
Format Journal Article
LanguageEnglish
Published US Oxford University Press 15.04.2020
Subjects
Apoptosis
B7 antigen
Cell activation
Cell death
Dysplasia
Genetic aspects
Head & neck cancer
Head and neck cancer
Immune checkpoint
Immunoglobulins
Immunohistochemistry
Interferon
Lymphocytes T
Macrophages
Medical prognosis
Mucosa
Prognosis
Squamous cell carcinoma
Tissue microarrays
Tryptophan 2,3-dioxygenase
China
IFITM3
Head and neck squamous cell carcinoma
Prognosis
IFIT1
Macrophage
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Summary:Abstract Objectives Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) and interferon-induced transmembrane protein 3 (IFITM3) are commonly induced by type I interferon. The study aims to investigate the expression and clinical significance of IFIT1 and IFITM3 in head and neck squamous cell carcinoma (HNSCC). Methods Immunohistochemistry was applied on tissue microarray to reveal IFIT1 and IFITM3 expression in 275 HNSCC, 69 dysplasia, and 42 normal mucosa samples. The clinicopathologic features associated with IFIT1 and IFITM3 expression in HNSCC patients were analyzed. Results IFIT1 and IFITM3 were highly expressed in HNSCC tissues. High expression of IFIT1 and IFITM3 predicts a negative prognosis for patients (P < .01). IFIT1 and IFITM3 expression was associated with programmed cell death ligand 1, B7-H4, V-domain Ig suppressor of T-cell activation, indoleamine 2,3-dioxygenase, and macrophage marker immunoreactivity. Conclusions IFIT1 and IFITM3 were overexpressed in HNSCC and indicated poor prognoses for patients with HNSCC. IFIT1 and IFITM3 expression was correlated with several immune checkpoint molecules and tumor-associated macrophage markers.
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ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqz205