Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
Thymoquinone, a component derived from the medial plant Nigella sativa , has been used for medical purposes for more than 2,000 years. Recent studies reported that thymoquinone exhibited inhibitory effects on cell proliferation of many cancer cell lines and hormone-refractory prostate cancer by supp...
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Published in | Molecular cancer therapeutics Vol. 7; no. 7; pp. 1789 - 1796 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for Cancer Research
01.07.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Thymoquinone, a component derived from the medial plant Nigella sativa , has been used for medical purposes for more than 2,000 years. Recent studies reported that thymoquinone exhibited inhibitory
effects on cell proliferation of many cancer cell lines and hormone-refractory prostate cancer by suppressing androgen receptor
and E2F-1. Whether thymoquinone inhibits tumor angiogenesis, the critical step of tumor growth and metastasis, is still unknown.
In this study, we found that thymoquinone effectively inhibited human umbilical vein endothelial cell migration, invasion,
and tube formation. Thymoquinone inhibited cell proliferation and suppressed the activation of AKT and extracellular signal-regulated
kinase. Thymoquinone blocked angiogenesis in vitro and in vivo , prevented tumor angiogenesis in a xenograft human prostate cancer (PC3) model in mouse, and inhibited human prostate tumor
growth at low dosage with almost no chemotoxic side effects. Furthermore, we observed that endothelial cells were more sensitive
to thymoquinone-induced cell apoptosis, cell proliferation, and migration inhibition compared with PC3 cancer cells. Thymoquinone
inhibited vascular endothelial growth factor–induced extracellular signal-regulated kinase activation but showed no inhibitory
effects on vascular endothelial growth factor receptor 2 activation. Overall, our results indicate that thymoquinone inhibits
tumor angiogenesis and tumor growth and could be used as a potential drug candidate for cancer therapy. [Mol Cancer Ther 2008;7(7):1789–96] |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1535-7163 1538-8514 |
DOI: | 10.1158/1535-7163.MCT-08-0124 |