White blood cell count as a risk factor for hypertension; a study of Japanese male office workers
To investigate the association of white blood cell (WBC) count with risk of hypertension. Cross-sectional and longitudinal studies. A work site in Japan. A total of 3776 Japanese male office workers aged 23-49 years were enrolled in this study; 2900 hypertension-free [systolic blood pressure (SBP) &...
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Published in | Journal of hypertension Vol. 20; no. 5; p. 851 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.05.2002
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Subjects | |
Online Access | Get more information |
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Summary: | To investigate the association of white blood cell (WBC) count with risk of hypertension.
Cross-sectional and longitudinal studies.
A work site in Japan.
A total of 3776 Japanese male office workers aged 23-49 years were enrolled in this study; 2900 hypertension-free [systolic blood pressure (SBP) < 140 mm Hg, diastolic blood pressure (DBP) < 90 mm Hg, no medication for hypertension, and no past history of hypertension] men were followed up over a 4-year period.
Blood pressure levels and the incidence of hypertension (SBP > or = 140 mm Hg and/or DBP > or = 90 mm Hg or medication for hypertension) according to WBC count at study entry.
After controlling for potential predictors of hypertension, SBP and DBP levels increased in a dose-dependent manner among both never-smokers and ex-smokers as WBC count increased. Among current smokers, only SBP level increased progressively with WBC count level. The multivariate-adjusted relative risk for development of hypertension compared with the first WBC count quintile was 1.29, 1.21, 1.67, and 1.92 among never-smokers (P for trend = 0.002): and 1.34, 1.46, 1.84, and 1.97 among ex-smokers (P for trend = 0.030) with the second, third, fourth, and fifth quintiles, respectively. Among current smokers, the respective multivariate-adjusted relative risks for hypertension relative to the first WBC count quintile were 0.91, 0.97, 1.08, and 0.84 (P for trend = 0.999).
WBC count is an important risk factor for hypertension, and the increased risk for hypertension associated with WBC count is more pronounced in non-smokers. |
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ISSN: | 0263-6352 |
DOI: | 10.1097/00004872-200205000-00018 |