Follicular variant of papillary thyroid carcinoma - a cytological study

• Published in: Cytopathology (Oxford) Vol. 15; no. 4; pp. 212 - 216
• Main Authors: Jogai, S., Adesina, A. O., Temmim, L., Al-Jassar, A., Amir, T., Amanguno, H. G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.08.2004
• Subjects: Biopsy, Fine-Needle - methods; Carcinoma, Papillary - pathology; Cell Nucleus - pathology; cytological features; fine neddle aspiration; follicular variant of papillary thyroid carcinoma; Humans; Nuclear Matrix - pathology; Thyroid Neoplasms - pathology
• ISSN: 0956-5507; 1365-2303
• DOI: 10.1111/j.1365-2303.2004.00168.x

The cytological diagnosis of classical papillary carcinoma is easily established based on the characteristic architectural and nuclear features. However, the follicular variant of papillary thyroid carcinoma(FVPTC) poses a diagnostic challenge. In this study we analysed the cytological features of 14 histopathologically proven cases of FVPTC. We inferred that a combination of architectural features such as follicles and syncytial clusters and nuclear features, viz grooves, pseudoinclusions and enlarged nuclei with fine chromatin, were helpful in establishing the diagnosis. It is hence suggested that based on the combination of the aforesaid features a diagnosis of FVPTC be offered whenever it is possible. This helps in patient management, obviating the need for a second surgical intervention.