Accelerated phase-contrast cine MRI using k-t SPARSE-SENSE

• Published in: Magnetic resonance in medicine Vol. 67; no. 4; pp. 1054 - 1064
• Main Authors: Kim, Daniel, Dyvorne, Hadrien A., Otazo, Ricardo, Feng, Li, Sodickson, Daniel K., Lee, Vivian S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2012
• Subjects: Adult; Algorithms; blood flow; Blood Flow Velocity; Cardiac-Gated Imaging Techniques; compressed sensing; Computer Simulation; Female; Humans; Image Enhancement - methods; Image Processing, Computer-Assisted - methods; liver; Liver - blood supply; Magnetic Resonance Imaging, Cine - instrumentation; Magnetic Resonance Imaging, Cine - methods; Male; MRI; parallel imaging; PC MRI; Phantoms, Imaging; velocity
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.23088

Phase‐contrast (PC) cine MRI is a promising method for assessment of pathologic hemodynamics, including cardiovascular and hepatoportal vascular dynamics, but its low data acquisition efficiency limits the achievable spatial and temporal resolutions within clinically acceptable breath‐hold durations. We propose to accelerate PC cine MRI using an approach which combines compressed sensing and parallel imaging (k‐t SPARSE‐SENSE). We validated the proposed 6‐fold accelerated PC cine MRI against 3‐fold accelerated PC cine MRI with parallel imaging (generalized autocalibrating partially parallel acquisitions). With the programmable flow pump, we simulated a time varying waveform emulating hepatic blood flow. Normalized root mean square error between two sets of velocity measurements was 2.59%. In multiple blood vessels of 12 control subjects, two sets of mean velocity measurements were in good agreement (mean difference = −0.29 cm/s; lower and upper 95% limits of agreement = −5.26 and 4.67 cm/s, respectively). The mean phase noise, defined as the standard deviation of the phase in a homogeneous stationary region, was significantly lower for k‐t SPARSE‐SENSE than for generalized autocalibrating partially parallel acquisitions (0.05 ± 0.01 vs. 0.19 ± 0.06 radians, respectively; P < 0.01). The proposed 6‐fold accelerated PC cine MRI pulse sequence with k‐t SPARSE‐SENSE is a promising investigational method for rapid velocity measurement with relatively high spatial (1.7 mm × 1.7 mm) and temporal (∼35 ms) resolutions. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.