Benzylpiperazine Derivatives. VII. Studies on the Role of the Nitrogen Atom in the Cerebral Vasodilating Activity of 1-Benzyl-4-diphenylmethylpiperazine Derivatives

1-Benzyl-4-diphenylmethylpiperidine derivatives were prepared to investigate the role of the nitrogen atom in their cerebral vasodilating activity. The pharmacological test results revealed that the piperidine derivatives are roughly equipotent to the piperazine derivatives in our test system. Struc...

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Published inChemical & pharmaceutical bulletin Vol. 35; no. 11; pp. 4637 - 4641
Main Authors OHTAKA, HIROSHI, KANAZAWA, TOSHIRO, ITO, KEIZO, TSUKAMOTO, GORO
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 1987
Japan Science and Technology Agency
Subjects
1-benzyl-4-diphenylmethylpiperidine
adaptive least-square method
Animals
Benzyl Compounds - chemical synthesis
Benzyl Compounds - pharmacology
bioisosterism
cerebral vasodilating activity
Cerebrovascular Circulation - drug effects
Chemical Phenomena
Chemistry
Dogs
Female
Leuckart-Wallach reaction
Male
piperazine
Piperazines - chemical synthesis
Piperazines - pharmacology
piperidine
regression analysis
Vasodilator Agents - chemical synthesis
Vasodilator Agents - pharmacology
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Summary:1-Benzyl-4-diphenylmethylpiperidine derivatives were prepared to investigate the role of the nitrogen atom in their cerebral vasodilating activity. The pharmacological test results revealed that the piperidine derivatives are roughly equipotent to the piperazine derivatives in our test system. Structure-activity analyses are presented.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.35.4637