Platelet function after intramuscular diclofenac

A randomised double-blind controlled study was performed to examine the effect of diclofenac on skin bleeding time and in vitro whole blood platelet aggregation. Twenty thoracotomy patients were studied; 10 were given diclofenac 75 mg intramuscularly at induction of anaesthesia, and 10 formed a cont...

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Bibliographic Details
Published inAnaesthesia Vol. 45; no. 11; p. 916
Main Authors Power, I, Chambers, W A, Greer, I A, Ramage, D, Simon, E
Format Journal Article
LanguageEnglish
Published England 01.11.1990
Subjects
Adult
Aged
Bleeding Time
Blood Platelets - drug effects
Blood Platelets - physiology
Diclofenac - administration & dosage
Diclofenac - pharmacology
Double-Blind Method
Female
Humans
Injections, Intramuscular
Intraoperative Period
Male
Middle Aged
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - pharmacology
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Summary:A randomised double-blind controlled study was performed to examine the effect of diclofenac on skin bleeding time and in vitro whole blood platelet aggregation. Twenty thoracotomy patients were studied; 10 were given diclofenac 75 mg intramuscularly at induction of anaesthesia, and 10 formed a control group. Skin bleeding times and platelet aggregation tests were performed the day before and repeated one hour after induction of anaesthesia. Diclofenac prolonged skin bleeding time and reduced platelet aggregation. There were no significant changes in the control group.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1990.tb14618.x