Potential benefit of laparoscopic surgery for rectal cancer on postoperative male sexual function

• Published in: Colorectal Disease Vol. 23; no. 7; pp. 1745 - 1754
• Main Authors: Kondo, Akihiro, Nishizawa, Yuji, Tsukada, Yuichiro, Sasaki, Takeshi, Inoue, Masaharu, Masuda, Hitoshi, Suzuki, Yasuyuki, Ito, Masaaki
• Format: Journal Article
• Language: English
• Published: England Wiley 01.07.2021; Wiley Subscription Services, Inc
• Subjects: Cancer; Cancer surgery; Colorectal cancer; Erectile Dysfunction; Humans; Ileostomy; laparoscopic surgery; Laparoscopy; Laparotomy; Lymph nodes; Male; male sexual dysfunction; Middle Aged; Multivariate analysis; Ostomy; Patients; Questionnaires; rectal cancer; Rectal Neoplasms; Rectum; Retrospective Studies; Surgery; Surveys and Questionnaires; male sexual dysfunction; laparoscopic surgery; rectal cancer
• ISSN: 1462-8910; 1463-1318; 1463-1318
• DOI: 10.1111/codi.15626

Aim The aim of this retrospective study was to evaluate the incidence of male sexual dysfunction after mid to low rectal cancer surgery and to identify factors associated with postoperative erectile and ejaculatory dysfunction. Methods The subjects were 410 consecutive male patients who underwent surgery for mid to low rectal cancer from 2009 to 2015. Two questionnaires on sexual function were administered: the International Index of Erectile Function, and an original questionnaire on ejaculatory status. Erectile and ejaculatory dysfunction were examined before and 3, 6, 12 months after surgery. In patients without preoperative dysfunction, multivariate regression analyses were performed to identify factors associated with the incidence of erectile and ejaculatory dysfunction at 12 months after surgery. Results Of 410 patients, 234 (57%) gave complete responses to the questionnaires, of whom 108 (46%) and 155 (66%) had severe erectile dysfunction, while 115 (49%) and 168 (72%) had severe ejaculatory dysfunction before and 12 months after surgery, respectively. Of the patients who maintained sexual function preoperatively, the incidence of erectile and ejaculatory dysfunction at 12 months after surgery was 51% (64/126) and 49% (58/119), respectively. In multivariate analysis, age >60 years (P = 0.02), laparotomy (P = 0.002), and creation of a diverting ileostomy (P = 0.003) were independent factors associated with postoperative erectile dysfunction, while age >60 years (P = 0.005), laparotomy (P = 0.04), and lateral lymph node dissection (P = 0.001) were independent factors associated with postoperative ejaculatory dysfunction. Conclusion Sexual dysfunction occurred in almost half of patients after rectal cancer surgery, and was independently associated with several factors, including laparotomy.