The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses

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Published inJournal of Virology Vol. 80; no. 22; pp. 11115 - 11123
Main Authors Li, Zejun, Jiang, Yongping, Jiao, Peirong, Wang, Aiqin, Zhao, Fengju, Tian, Guobin, Wang, Xijun, Yu, Kangzhen, Bu, Zhigao, Chen, Hualan
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2006
Subjects
Amino Acid Substitution
Animals
Avian influenza virus
Biological and medical sciences
Chick Embryo
Chickens
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Genetics
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - virology
Interferons - antagonists & inhibitors
Microbiology
Mutation, Missense
Nucleoproteins - genetics
Nucleoproteins - physiology
Pathogenesis and Immunity
Recombination, Genetic
RNA Replicase - genetics
RNA Replicase - physiology
RNA-Binding Proteins - genetics
RNA-Binding Proteins - physiology
Viral Core Proteins - genetics
Viral Core Proteins - physiology
Viral Matrix Proteins - genetics
Viral Matrix Proteins - physiology
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - physiology
Viral Proteins - genetics
Viral Proteins - physiology
Virology
Virulence - genetics
Virus Replication - genetics
Virus
Influenzavirus A
Gene
Avian influenzavirus
Infectivity
Virulence
Host range
Orthomyxoviridae
Property structure relationship
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Corresponding authors. Mailing address: Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People's Republic of China. Phone for Z. Bu: 86-451-85935062. Fax: 86-451-82733132. E-mail: zgb@hvri.ac.cn. Phone for H. Chen: 86-451-85935079. Fax: 86-451-82761925. E-mail: hlchen1@yahoo.com.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00993-06