No apparent cost of evolved immune response in Drosophila melanogaster

• Published in: Evolution Vol. 70; no. 4; pp. 934 - 943
• Main Authors: Gupta, Vanika, Venkatesan, Saudamini, Chatterjee, Martik, Syed, Zeeshan A., Nivsarkar, Vaishnavi, Prasad, Nagaraj G.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2016; Society for the Study of Evolution; Oxford University Press
• Subjects: Animals; Biological Evolution; BRIEF COMMUNICATIONS; Drosophila melanogaster; Drosophila melanogaster - immunology; Drosophila melanogaster - physiology; Female; Fertility; Genetic Fitness; Infections; Insects; life history; Longevity; Male; Ovum - physiology; Pseudomonas; trade-offs; trade-offs; Drosophila melanogaster; life history
• ISSN: 0014-3820; 1558-5646
• DOI: 10.1111/evo.12896

Maintenance and deployment of the immune system are costly and are hence predicted to trade-off with other resource-demanding traits, such as reproduction. We subjected this longstanding idea to test using laboratory experimental evolution approach. In the present study, replicate populations of Drosophila melanogaster were subjected to three selection regimes—I (Infection with Pseudomonas entomophila), S (Sham-infection with MgSO4), and U (Unhandled Control). After 30 generations of selection files from the I regime had evolved better survivorship upon infection with P. entomophila compared to flies from U and S regimes. However, contrary to expectations and previous reports, we did not find any evidence of trade-offs between immunity and other life history related traits, such as longevity, fecundity, egg hatchability, or development time. After 45 generations of selection, the selection was relaxed for a set of populations. Even after 15 generations. the postinfection survivorship of populations under relaxed selection regime did not decline. We speculate that either there is a negligible cost to the evolved immune response or that trade-offs occur on traits such as reproductive behavior or other immune mechanisms that we have not investigated in this study. Our research suggests that at least under certain conditions, life-history trade-offs might play little role in maintaining variation in immunity.