Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

• Published in: The Journal of pathology Vol. 226; no. 2; pp. 172 - 184
• Main Authors: Christensen, Søren T, Clement, Christian A, Satir, Peter, Pedersen, Lotte B
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2012
• Subjects: Cell Communication - physiology; Cell Cycle - physiology; cell cycle control; cell differentiation; Cell Differentiation - physiology; cell migration; Cell Movement - physiology; Cilia - chemistry; Cilia - physiology; EGFR; ErbB Receptors - physiology; FGFR; Humans; IGF1R; PDGFRα; primary cilia; Receptor Protein-Tyrosine Kinases - physiology; receptor tyrosine kinase (RTK); Receptor, IGF Type 1 - physiology; Receptor, Platelet-Derived Growth Factor alpha - physiology; Receptors, Fibroblast Growth Factor - physiology; Signal Transduction - physiology; signal transduction and crosstalk; signalling networking; Tie1/2
• ISSN: 0022-3417; 1096-9896
• DOI: 10.1002/path.3004

Primary cilia are microtubule‐based sensory organelles that coordinate signalling pathways in cell‐cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.