Enhancement of the water solubility and antioxidant activity of hesperidin by chitooligosaccharide

BACKGROUND Hesperidin is a natural product and a strong antioxidant with potential applications in various food and pharmaceutical products. However, its poor water solubility greatly limits its applications. RESULTS In this study, chitooligosaccharide (COS) was applied to prepare a stable complex w...

Full description

Saved in:
Bibliographic Details
Published inJournal of the science of food and agriculture Vol. 98; no. 6; pp. 2422 - 2427
Main Authors Cao, Ruge, Zhao, Yali, Zhou, Zhongkai, Zhao, Xiaoyu
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.04.2018
John Wiley and Sons, Limited
Subjects
antioxidant activity
Antioxidants
Aromatic compounds
Chemical bonds
chitooligosaccharide
chitooligosaccharides
complex
drugs
Drying
Electron microscopy
Food production
Fourier transforms
Hesperidin
Hydrogen bonding
Infrared analysis
Infrared spectroscopy
Magnetic resonance spectroscopy
NMR
Nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
Scanning electron microscopy
Solubility
Spectroscopy
Spectrum analysis
spray drying
Thermogravimetric analysis
thermogravimetry
water solubility
chitooligosaccharide
solubility
antioxidant activity
complex
hesperidin
Online AccessGet full text

Cover

More Information
Summary:BACKGROUND Hesperidin is a natural product and a strong antioxidant with potential applications in various food and pharmaceutical products. However, its poor water solubility greatly limits its applications. RESULTS In this study, chitooligosaccharide (COS) was applied to prepare a stable complex with hesperidin (Hesp‐COS) via the spray‐drying method at 100 °C for 20 min. The resultant complex was characterized by Fourier transformation infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and proton nuclear magnetic resonance spectroscopy. It was demonstrated that the aromatic rings of hesperidin interacted with COS through hydrogen bonding and formed Hesp‐COS complex. As a result, both the water solubility and antioxidant activity of Hesp‐COS were higher than that of the free hesperidin. CONCLUSION The preparation conditions of Hesp‐COS in this study were efficient and produced an increment in both the water solubility and antioxidant activity of hesperidin. © 2017 Society of Chemical Industry
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0022-5142
1097-0010
1097-0010
DOI:10.1002/jsfa.8734