Spectrally Resolved Magnetic Resonance Imaging of a Xenon Biosensor

Going hyper: A continuous flow of water saturated with hyperpolarized xenon through a glass tube assembly containing a xenon biosensor attached through its biotin tag to immobilized avidin–agarose beads (see picture) packed in between two frits results in distinct NMR signals that allow detection of...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 45; no. 1; pp. 70 - 73
Main Authors Hilty, Christian, Lowery, Thomas J., Wemmer, David E., Pines, Alexander
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.12.2005
WILEY‐VCH Verlag
Subjects
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
biosensors
cage compounds
imaging agents
Magnetic Resonance Imaging
Molecular Structure
xenon
Xenon - analysis
Xenon - chemistry
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Summary:Going hyper: A continuous flow of water saturated with hyperpolarized xenon through a glass tube assembly containing a xenon biosensor attached through its biotin tag to immobilized avidin–agarose beads (see picture) packed in between two frits results in distinct NMR signals that allow detection of the immobilized avidin analyte with high sensitivity.
Bibliography:ark:/67375/WNG-C3SX68ZW-2
This work was supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the US Department of Energy under Contract No. DE-AC03-76SF00098. C.H. acknowledges support from the Schweizerischer Nationalfonds through a postdoctoral fellowship. T.L. acknowledges support from the University of California Biotechnology Research and Education Program for a training grant.
istex:9F33D56CC882F91DC554B7B81AEFB85DCB3E5DAA
ArticleID:ANIE200502693
This work was supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the US Department of Energy under Contract No. DE‐AC03‐76SF00098. C.H. acknowledges support from the Schweizerischer Nationalfonds through a postdoctoral fellowship. T.L. acknowledges support from the University of California Biotechnology Research and Education Program for a training grant.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502693