P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin

• Published in: BioMed research international Vol. 2019; no. 2019; pp. 1 - 9
• Main Authors: Chen, Suxian, Zhang, Tong, Tan, Qi, Gu, Zehui, Zhang, Yang, Ren, Liqun, Li, Qi, Qin, Meng
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; Hindawi Limited
• Subjects: Anticancer properties; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Biological products; Breast cancer; Cancer; Caspase; Caspases - metabolism; Cell cycle; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell viability; Chemical compounds; Cofactors; Drug dosages; Drug Therapy, Combination; Flavonoids; G1 Phase - drug effects; Gastric cancer; Genomics; Hepatotoxicity; Humans; Kinases; MAP Kinase Signaling System - drug effects; Medical prognosis; Morphology; Ototoxicity; Oxaliplatin; Oxaliplatin - pharmacology; Pharmacology; Proteins; Resting Phase, Cell Cycle - drug effects; Rutin; Rutin - pharmacology; Sensitivity enhancement; Side effects; Signal transduction; Signal Transduction - drug effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism; Synergism; Toxicity; Tumors; Beijing China; United States > US; China; Japan
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2019/6407210

Currently, gastric cancer treatment is mainly based on first-line intervention with oxaliplatin (OXA) after surgical resection, but the application of OXA has been limited due to the toxic side effects caused by the cumulative dose. The toxicity of OXA mainly includes hepatotoxicity, nephrotoxicity, and ototoxicity, and there is an urgent clinical need to find alternatives that are less toxic and more effective. Rutin (RT) is a natural flavonoid with many biological activities. Studies have found that RT inhibits tumor cell growth and enhances their sensitivity toward certain drugs. As the underlying impact of RT on gastric cancer and its molecular mechanism remain poorly understood, we performed a series of experiments to determine whether RT has the effect of treating gastric cancer, and whether it can cooperate with OXA to treat gastric cancer and its related mechanisms. In the present study, we founded that RT suppressed cell viability, inhibited cell proliferation by causing G0/G1 arrest, and induced apoptosis in SGC 7901 cells. And RT can play as an antitumor agent together with OXA. The mechanism of RT-induced apoptosis may be associated with the activation of the p38/Caspase signal pathway. These results demonstrated the potential of RT as a promising therapeutic compound to treat gastric cancer. At the same time, RT can synergize with OXA to reduce the dose of OXA and reduce the toxicity.