Carcinoma showing thymic-like elements-a rare malignancy of the thyroid gland
Background: Carcinoma showing thymic‐like elements (CASTLE) is a rare tumour of the thyroid of thymic origin. The histological appearance of this tumour may be similar to that of squamous cell carcinoma of the thyroid, but outcome associated with CASTLE is more favourable. Methods: A systematic lite...
Saved in:
Published in | British journal of surgery Vol. 91; no. 2; pp. 142 - 145 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.02.2004
Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Background:
Carcinoma showing thymic‐like elements (CASTLE) is a rare tumour of the thyroid of thymic origin. The histological appearance of this tumour may be similar to that of squamous cell carcinoma of the thyroid, but outcome associated with CASTLE is more favourable.
Methods:
A systematic literature review was conducted for case reports on CASTLE. A text word search of the Medline database was made with a manual search of the citations from these references. Twenty‐two case reports were found.
Results:
In five patients with tumour‐negative lymph nodes no local or distant recurrence was observed. Seventeen patients had unknown or involved lymph nodes. Two patients were excluded from further study: one had no follow‐up and one was treated by irradiation only. Of the remaining 15, six had local, three had distant and two had local and distant recurrence. In patients with involved or unknown lymph node status, local recurrence was noted in one of five patients treated by surgery and irradiation, and in seven of ten patients treated by surgery alone. Irradiation or systemic chemotherapy was given to four patients with recurrent tumours, with variable response.
Conclusion:
CASTLE with tumour‐negative lymph nodes has a low risk of recurrence and surgery without adjuvant therapy is sufficient. Radiotherapy seems indicated when lymph nodes are tumour positive and can be effective for recurrent tumours. In selected patients surgery for recurrent tumour can improve quality of life and outcome. Copyright © 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Another thyroid cancer with a fairly good prognosis |
---|---|
Bibliography: | istex:3ABAE10907222EA148F8BBC4280D31F4089BCFA2 ArticleID:BJS4510 ark:/67375/WNG-600L51DG-M SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-6 ObjectType-Review-2 ObjectType-Case Study-4 ObjectType-Undefined-1 ObjectType-Report-3 ObjectType-Article-5 |
ISSN: | 0007-1323 1365-2168 |
DOI: | 10.1002/bjs.4510 |