Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls

• Published in: Journal of reproductive immunology Vol. 156; p. 103821
• Main Authors: Sabharwal, Vishakha, Demos, Riley, Snyder-Cappione, Jennifer, Parker, Samantha E., Shaik-Dasthagirisaheb, Yazdan, Hunnewell, Jessica, Boateng, Jeffery, Clarke, Katherine, Yuen, Rachel, Barnett, Elizabeth, Yarrington, Christina, Taglauer, Elizabeth, Wachman, Elisha M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2023
• Subjects: COVID-19; COVID-19 - prevention & control; COVID-19 Vaccines; Cytokines; Female; Humans; Infant; Pregnancy; Prospective Studies; SARS-CoV-2; Short Communication; Vaccination; IFN-λ1; Cytokines; IFN-λ2/3; CI; LNPs; Vaccination; mRNA; L&D; IQR; IP-10; IL-8; IL-1β; IFN-α2; IL-6; COVID-19; SARS-CoV-2; IFN-γ; TNF-α; GM-CSF; MD; BMC; IL-12p70; IFN- β
• ISSN: 0165-0378; 1872-7603
• DOI: 10.1016/j.jri.2023.103821

The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants.