Recent pharmacological advances in the treatment of cardiovascular events with Astragaloside IV

• Published in: Biomedicine & pharmacotherapy Vol. 168; p. 115752
• Main Authors: Xu, Zehui, Zhou, Houle, Zhang, Yihan, Cheng, Ziji, Wan, Melisandre, Qin, Wanting, Li, Peiyu, Feng, Jiaming, Shao, Shuijin, Xue, Wenlong, Guo, Haidong, Liu, Baonian
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.12.2023; Elsevier
• Subjects: Astragaloside IV; Cardiovascular diseases; Pharmacological mechanism; Traditional Chinese medicine; CHF; LVW/BW; BNP; CLP; LVEF; LV; HIF-1α; Astragaloside IV; I/R; TNF; PBA; ADR; NF-κB; AS-IV; MRAs; MD; MI; CCN1; AMI; Tfr cells; SUMO; IL; Pharmacological mechanism; Nrf-2; BMECs; DOX; DCM; CVD; AS; HPASMC; Tfh cells; VSMC; Cardiovascular diseases; HUVECs; LPC; TCM; LVSED; BLM; HO-1; Spen1; LDH; NLR; ACE; CF; ISO; Traditional Chinese medicine; LVEDD; Ox-LDL; LVFS; PAH; ARBs; HF; MCT; LVH
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2023.115752

Cardiovascular disease (CVD) remains the leading cause of death and disability globally. A wide range of CVDs have been reported, each of which diverges significantly, exhibiting sophisticated types of pathogenesis (e.g., inflammatory, oxidative stress, and disorders in cardiomyocyte metabolism). Compared with conventional treatments in modern medicine, traditional Chinese medicine (TCM) can exhibit comparative advantages in the treatment of CVDs. TCM can be utilized to develop effective strategies for addressing the challenges of CVD, with fewer side effects and higher therapeutic efficiency. Astragaloside IV (AS-IV) has been confirmed as one of the major active ingredients found in Astragalus membranaceus (a Chinese herbal medicine that has been extensively employed clinically for the treatments of CVDs). Since recent studies have shown that AS-IV in CVD treatments has achieved promising results, the substance has aroused great attention and further discussions in the field. The present review aims to summarize the recent pharmacological advances in employing AS-IV in the treatment of CVDs. [Display omitted] •Traditional Chinese medicine (TCM) can be utilized to develop effective strategies for addressing the challenges of cardiovascular events.•Astragaloside IV, as a major active ingredient of TCM, can be a new candidate drug for treating cardiovascular events.•Astragaloside IV protects cardiovascular via several effects, including anti-inflammation, anti-oxidation, anti-apoptosis, and anti-fibrosis.