Role of phytoconstituents in the management of COVID-19

• Published in: Chemico-biological interactions Vol. 341; p. 109449
• Main Authors: Das, Amiya, Pandita, Deepti, Jain, Gaurav Kumar, Agarwal, Pallavi, Grewal, Ajmer Singh, Khar, Roop K., Lather, Viney
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 25.05.2021
• Subjects: ACE-2; Alkaloids - chemistry; Alkaloids - pharmacology; Anthraquinones - chemistry; Anthraquinones - pharmacology; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; COVID-19; COVID-19 Drug Treatment; COVID-19 main protease; Flavonoids - chemistry; Flavonoids - pharmacology; Humans; nCoV-2019; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Phytochemicals - chemistry; Phytochemicals - pharmacology; Phytoconstituents; Plants, Medicinal - chemistry; Plants, Medicinal - metabolism; Saponins - chemistry; Saponins - pharmacology; Secondary Metabolism; TMPRSS2; COVID-19; COVID-19 main protease; TMPRSS2; ACE-2; nCoV-2019; Phytoconstituents
• ISSN: 0009-2797; 1872-7786; 1872-7786
• DOI: 10.1016/j.cbi.2021.109449

COVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas. This review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry through host cell receptors. The use of medicinal plants containing specific phytomoieties could be seen in providing a safer and long-term solution for the population with lesser side effects. Key Findings and Conclusions: Considering the high cost and time-consuming drug discovery process, therapeutic repositioning of existing drugs was explored as treatment option in COVID-19, however several molecules have been retracted as therapeutics either due to no positive outcomes or the severe side effects. These effects call for exploring the alternate treatment options which are therapeutically effective as well as safe. Keeping this in mind, phytopharmaceuticals derived from medicinal plants could be explored as important resources in the development of COVID-19 treatment, as their role in the past for treatment of viral diseases like HIV, MERS-CoV, and influenza has been well reported. Considering this fact, different phytoconstituents such as flavonoids, alkaloids, tannins and glycosides etc. Possessing antiviral properties against coronaviruses and possessing potential against SARS-CoV-2 have been reviewed in the present work. [Display omitted] •COVID-19 has emerged as most threatening global pandemic.•Therapeutic treatment of COVID-19 has resulted in limited outcomes.•Phytopharmaceuticals derived from medicinal plants may provide alternate safer and effective treatment options.