C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity
C-reactive protein (CRP) is an acute-phase serum protein and a member of the pentraxin protein family. Its host defense functions predate the adaptive immune system by millions of years. Our current understanding of CRP interactions with complement and with Fcgamma receptors (FcgammaR) have led to a...
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Published in | Immunologic research Vol. 30; no. 3; pp. 261 - 278 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Springer Nature B.V
01.01.2004
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Subjects | |
Online Access | Get full text |
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Summary: | C-reactive protein (CRP) is an acute-phase serum protein and a member of the pentraxin protein family. Its host defense functions predate the adaptive immune system by millions of years. Our current understanding of CRP interactions with complement and with Fcgamma receptors (FcgammaR) have led to an increased appreciation of the regulatory role of CRP in inflammation and autoimmunity. This review outlines the role of CRP in infection, inflammation, and autoimmune disease. We provide a description of recent studies, which suggest that CRP acts through FcgammaR to reduce inflammation and protect from certain autoimmune diseases. A general description of the proposed function of CRP is provided as a framework for future investigation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0257-277X 0257-277X 1559-0755 |
DOI: | 10.1385/ir:30:3:261 |