Clinicopathological and genetic findings of infantile nodular fasciitis

Recent findings indicated that recurrent gene rearrangement of ubiquitin-specific protease 6 (USP6), located at 17p13.2, favors the clonally proliferative nature of NF. Immunohistochemical staining was conducted, and all the cases with available data were positive for smooth muscle actin (SMA) [Figu...

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Bibliographic Details
Published inChinese medical journal Vol. 134; no. 22; pp. 2768 - 2770
Main Authors Qiu, Yan, Hu, Xue, He, Xin, Zeng, Wen-Jing, Zhang, Hong-Ying
Format Journal Article
LanguageEnglish
Published China Lippincott Williams & Wilkins Ovid Technologies 20.11.2021
Lippincott Williams & Wilkins
Wolters Kluwer
Subjects
Correspondence
Diagnosis, Differential
Fasciitis - diagnosis
Fasciitis - genetics
Fibroma
Humans
Panniculitis
Sarcoma
Tumors
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Summary:Recent findings indicated that recurrent gene rearrangement of ubiquitin-specific protease 6 (USP6), located at 17p13.2, favors the clonally proliferative nature of NF. Immunohistochemical staining was conducted, and all the cases with available data were positive for smooth muscle actin (SMA) [Figure 1D] and negative for desmin. [1,2] Considering the limitation of the traditional RT-PCR method, such as limitations of reported primers and relative low detection sensitivity, further molecular studies such as next generation sequencing based technology are needed in discovering other occult or novel alterations. [1]USP6 rearrangements have been identified in infantile NFs but not in any of the abovementioned histologic mimics. [...]USP6 status, combined with the clinicopathologic, molecular, and genetic characteristics of infantile NF histologic mimics, can be useful in the diagnosis-making process.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000001727