Molecular Subtypes and Local-Regional Control of Breast Cancer

In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. Research efforts have focused on how classification of subtypes could provide information on prognosis and influence treatment planning. Although much is known about t...

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Bibliographic Details
Published inSurgical oncology clinics of North America Vol. 27; no. 1; p. 95
Main Authors Fragomeni, Simona Maria, Sciallis, Andrew, Jeruss, Jacqueline S
Format Journal Article
LanguageEnglish
Published United States 01.01.2018
Subjects
Biomarkers, Tumor - genetics
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Female
Gene Expression Profiling - methods
Humans
Precision Medicine - methods
Local-regional recurrence
Molecular subtypes
Breast cancer
Gene signatures
Immunohistochemical surrogates
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Summary:In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. Research efforts have focused on how classification of subtypes could provide information on prognosis and influence treatment planning. Although much is known about the impact of different molecular subtypes on disease-specific survival, more recent studies have investigated the role of the different molecular subtypes on local-regional recurrence. This is an area of active study, and in recent years there has been significant progress. This article describes outcomes among disease subtypes to aid in optimal surgical decision-making to improve local-regional control.
ISSN:1558-5042
DOI:10.1016/j.soc.2017.08.005