Self-assembly of dental surface nanofilaments and remineralisation by SnF2 and CPP-ACP nanocomplexes

• Published in: Scientific reports Vol. 9; no. 1; p. 1285
• Main Authors: Fernando, James R., Shen, Peiyan, Sim, Christina P. C., Chen, Yu-Yen, Walker, Glenn D., Yuan, Yi, Reynolds, Coralie, Stanton, David P., MacRae, Colin M., Reynolds, Eric C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.02.2019; Nature Publishing Group
• Subjects: 101/28; 14; 14/28; 631/61/350/2093; 639/925/350/354; Biomimetics; Calcium phosphates; Casein; Clinical trials; Dental caries; Health problems; Humanities and Social Sciences; Hypersensitivity; multidisciplinary; Nanotechnology; Public health; Science; Science (multidisciplinary); Self-assembly; Teeth
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-37580-w

Dental caries, erosion and hypersensitivity are major public health problems. SnF 2 is used widely in oral care products to help prevent/treat these conditions. Casein phosphopeptide-stabilised amorphous calcium phosphate nanocomplexes (CPP-ACP) are a biomimetic nanotechnology of salivary phosphopeptide-ACP complexes that deliver bioavailable calcium and phosphate ions to promote dental remineralisation (repair). We show here using in vitro studies and a double-blind, randomised controlled, cross-over design in situ clinical trial that SnF 2 and CPP-ACP interact to form a nanofilament coating on the tooth surface and that together they are superior in their ability to promote dental remineralisation. Sn(II) by cross-linking the CPP-ACP helps to stabilise the complexes which improves delivery to the tooth surface and enhances binding and ion incorporation into tooth mineral. The combination of SnF 2 and CPP-ACP in oral care products may significantly improve their efficacy in prevention/treatment of dental caries/erosion and hypersensitivity.