Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN–LSTM model

• Published in: Computer methods and programs in biomedicine Vol. 250; p. 108196
• Main Authors: Xu, Yongjie, Yu, Zengjie, Li, Yisheng, Liu, Yuehan, Li, Ye, Wang, Yishan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.06.2024
• Subjects: Adolescent; Algorithms; Autism spectrum disorder; Autism Spectrum Disorder - diagnosis; Autism Spectrum Disorder - physiopathology; Brain - diagnostic imaging; Brain - physiopathology; Brain functional connectivity; Brain Mapping - methods; Child; Deep learning; EEG; Electroencephalography - methods; Female; Humans; Male; Neural Networks, Computer; Signal Processing, Computer-Assisted; Deep learning; Brain functional connectivity; EEG; Autism spectrum disorder
• ISSN: 0169-2607; 1872-7565; 1872-7565
• DOI: 10.1016/j.cmpb.2024.108196

People with autism spectrum disorder (ASD) often have cognitive impairments. Effective connectivity between different areas of the brain is essential for normal cognition. Electroencephalography (EEG) has been widely used in the detection of neurological diseases. Previous studies on detecting ASD with EEG data have focused on frequency-related features. Most of these studies have augmented data by splitting the dataset into time slices or sliding windows. However, such approaches to data augmentation may cause the testing data to be contaminated by the training data. To solve this problem, this study developed a novel method for detecting ASD with EEG data. This study quantified the functional connectivity of the subject’s brain from EEG signals and defined the individual to be the unit of analysis. Publicly available EEG data were gathered from 97 and 92 subjects with ASD and typical development (TD), respectively, while they were at rest or performing a task. Time-series maps of brain functional connectivity were constructed, and the data were augmented using a deep convolutional generative adversarial network. In addition, a combined network for ASD detection, based on convolutional neural network (CNN) and long short-term memory (LSTM), was designed and implemented. Based on functional connectivity, the network achieved classification accuracies of 81.08% and 74.55% on resting state and task state data, respectively. In addition, we found that the functional connectivity of ASD differed from TD primarily in the short-distance functional connectivity of the parietal and occipital lobes and in the distant connections from the right temporoparietal junction region to the left posterior temporal lobe. This paper provides a new perspective for better utilizing EEG to understand ASD. The method proposed in our study is expected to be a reliable tool to assist in the diagnosis of ASD. •This study constructed TSM-BFCs by combining the temporal information in EEG signals with the individual taken as the unit of analysis.•A CNN–LSTM model for ASD detection that leverages the temporal and spatial features of EEG signals was designed.