Comparing caloric restriction regimens for effective weight management in adults: a systematic review and network meta-analysis

• Published in: The international journal of behavioral nutrition and physical activity Vol. 21; no. 1; pp. 108 - 17
• Main Authors: Huang, Jinming, Li, Yi, Chen, Maohua, Cai, Zhaolun, Cai, Zhen, Jiang, Zhiyuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.09.2024; BioMed Central; BMC
• Subjects: Adult; Adults; Alternate day fasting; Analysis; Bayes Theorem; Body Mass Index; Body Weight; Caloric Restriction - methods; Calorie restriction; Chronic diseases; Dextrose; Fasting; Glucose; Health aspects; Humans; Intermittent fasting; Life style; Network Meta-Analysis; Obesity - therapy; Prevention; Randomized Controlled Trials as Topic; Review; Risk factors; Short-term fasting; Time restrict eating; Type 2 diabetes; Weight Loss; Weight loss maintenance; China; Alternate day fasting; Time restrict eating; Body weight; Intermittent fasting; Short-term fasting; Calorie restriction
• ISSN: 1479-5868; 1479-5868
• DOI: 10.1186/s12966-024-01657-9

Randomized controlled trials have confirmed the effectiveness of four prevalent caloric restriction regimens in reducing obesity-related health risks. However, there is no consensus on the optimal regimen for weight management in adults. We systematically searched PubMed, Embase, Web of Science, and Cochrane CENTRAL up to January 15, 2024, for randomized controlled trials (RCT) involving adults, evaluating the weight-loss effects of alternate day fasting (ADF), short-term fasting (STF), time-restricted eating (TRE), and continuous energy restriction (CER). The primary outcome was body weight, with secondary outcomes including BMI, fat mass, lean mass, waist circumference, fasting glucose, HOMA-IR, and adverse events. Bayesian network meta-analysis was conducted, ranking regimens using the surface under the cumulative ranking curve and the probability of being the best. Study quality was assessed using the Confidence in Network Meta-Analysis tool. Data from 47 RCTs (representing 3363 participants) were included. ADF showed the most significant body weight loss (Mean difference (MD): -3.42; 95% Confidence interval (CI): -4.28 to -2.55), followed by TRE (MD: -2.25; 95% CI: -2.92 to -1.59). STF (MD: -1.87; 95% CI: -3.32 to -0.56) and CER (MD: -1.59; 95% CI: -2.42 to -0.79) rank third and fourth, respectively. STF lead to decline in lean mass (MD: -1.26; 95% CI: -2.16, -0.47). TRE showed benefits on fasting glucose (MD: -2.98; 95% CI: -4.7, -1.26). Subgroup analysis revealed all four caloric restriction regimens likely lead to modest weight loss after 1-3 months, with ADF ranked highest, but by 4-6 months, varying degrees of weight regain occur, particularly with CER, while interventions lasting 7-12 months may result in effective weight loss, with TRE potentially ranking first during both the 4-6 months and 7-12 months periods. ADF showing fewer and shorter-lasting physical symptoms. All four included regiments were effective in reducing body weight, with ADF likely having the most significant impact. Each regimen likely leads to modest weight loss after 1-3 months, followed by weight regain by 4-6 months. However, interventions lasting 7-12 months achieve greater weight loss overall. PROSPERO: CRD42022382478.