Inhibitory study of two cephalosporins on E. coli by microcalorimetry

• Published in: Journal of thermal analysis and calorimetry Vol. 100; no. 2; pp. 589 - 592
• Main Authors: Yang, L. N., Sun, Li Xian, Xu, Fen, Zhang, J., Zhao, J. N., Zhao, Z. B., Song, C. G., Wu, R. H., Ozao, Riko
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2010; Springer
• Subjects: Analytical Chemistry; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteriology; Biological and medical sciences; Cephaloridine; Cephalosporins; Chemistry; Chemistry and Materials Science; Escherichia coli; Fundamental and applied biological sciences. Psychology; Growth, nutrition, cell differenciation; Inorganic Chemistry; Measurement Science and Instrumentation; Medical sciences; Microbiology; Moxalactam; Pharmacology. Drug treatments; Physical Chemistry; Polymer Sciences; DH5α; Cefpiramide; Cephalosporins; Ceftizoxime sodium; Inhibition; Microcalorimetry; Metabolism; Microorganism growth; Ceftizoxime; Escherichia coli; Lactam; Biological activity; Cephalosporin derivatives; Antibiotic; E. coli DH5α; Bacteria; Thermal analysis; Thermokinetics; Antibacterial agent; Enterobacteriaceae
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-009-0222-1

The microcalorimetric method has been used to study the effects of cefpiramide and ceftizoxime sodium on the E. coli growth. The results revealed that these two cephalosporins may alter the metabolic way of the E. coli . Moreover, the lethal doses of cefpiramide and ceftizoxime sodium are 2.000 and 0.2000 μg mL −1 , respectively. Combining with the relationships between growth rate constant ( k ), the maximum power output ( P m ), the time corresponding to the maximum power output ( t m ) and cephalosporins concentration ( C ), one can draw the conclusion that the ceftizoxime sodium has a stronger inhibition effects on the growth of E. coli than that of cefpiramide and they both have the possibility to induce the drug fever.