No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis

• Published in: The Journal of infectious diseases Vol. 188; no. 8; pp. 1116 - 1118
• Main Authors: Ma, Xin, Reich, Robert A., Gonzalez, Omar, Pan, Xi, Fothergill, Amanda K., Starke, Jeffery R., Teeter, Larry D., Musser, James M., Graviss, Edward A.
• Format: Journal Article
• Language: English
• Published: United States The University of Chicago Press 15.10.2003; University of Chicago Press; Oxford University Press
• Subjects: 3' Untranslated Regions - genetics; Adult; African Americans; Alleles; Bacteria; Black or African American; Black People; Case-Control Studies; Child; Female; Genetic Predisposition to Disease; Humans; Infections; Infectious diseases; Interleukin-12 - genetics; Interleukin-12 Subunit p40; Linkage Disequilibrium; Male; Mycobacterium tuberculosis; Pediatrics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Pulmonary tuberculosis; Three prime untranslated regions; Tuberculosis; Tuberculosis, Pulmonary - ethnology; Tuberculosis, Pulmonary - genetics; Untranslated regions; White People
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/378674

Interleukin (IL)–12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB