The significance of isolated Y chromosome loss in bone marrow metaphase cells from males over age 50 years

• Published in: Leukemia research Vol. 35; no. 10; pp. 1297 - 1300
• Main Authors: Wiktor, Anne E, Van Dyke, Daniel L, Hodnefield, Janice M, Eckel-Passow, Jeanette, Hanson, Curtis A
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2011
• Subjects: Acute myeloid leukemia; Adult; Aged; Bone Marrow - pathology; Bone Marrow Cells - pathology; Chromosome Deletion; Chromosomes, Human, Y; Cytogenetics; Hematology, Oncology and Palliative Medicine; Humans; Karyotyping; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; Male; Metaphase - genetics; Middle Aged; Myelodysplasia; Myelodysplastic Syndromes - diagnosis; Myelodysplastic Syndromes - genetics; Myelodysplastic Syndromes - pathology; Retrospective Studies; Y chromosome loss; Y chromosome loss; Cytogenetics; Myelodysplasia; Acute myeloid leukemia
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2011.05.002

Abstract To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis.