Testosterone Replacement Therapy in Hypogonadal Men

All approved testosterone replacement methods, when used according to recommendations, can restore normal serum testosterone concentrations, and relieve symptoms in most hypogonadal men. Selection of the method depends on the patient's preference with advice from the physician. Dose adjustment...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 51; no. 1; p. 77
Main Authors Wang, Christina, Swerdloff, Ronald S
Format Journal Article
LanguageEnglish
Published United States 01.03.2022
Subjects
Androgens - therapeutic use
Hormone Replacement Therapy
Humans
Hypogonadism - drug therapy
Male
Spermatogenesis
Testosterone - adverse effects
Implants
Intramuscular injections
Modified androgens
Endogenous testosterone stimulators
Oral capsules
Selective androgen receptor modulators
Transdermal gels
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Summary:All approved testosterone replacement methods, when used according to recommendations, can restore normal serum testosterone concentrations, and relieve symptoms in most hypogonadal men. Selection of the method depends on the patient's preference with advice from the physician. Dose adjustment is possible with most delivery methods but may not be necessary in all hypogonadal men. The use of hepatotoxic androgens must be avoided. Testosterone treatment induces reversible suppression of spermatogenesis; if fertility is desired in the near future, human chronic gonadotropin, selective estrogen receptor modulator, estrogen antagonist, or an aromatase inhibitor that stimulates endogenous testosterone production may be used.
ISSN:1558-4410
DOI:10.1016/j.ecl.2021.11.005