Sensing Mitochondrial Acetyl-CoA to Tune Respiration
Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for...
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| Published in | Trends in endocrinology and metabolism Vol. 30; no. 1; pp. 1 - 3 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
01.01.2019
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| Abstract | Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration. |
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| AbstractList | Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken
et al
. [
1
] (
Mol. Cell
2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration. Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration. |
| Author | Hirschey, Matthew D. Mills, Christine A. Trub, Alec G. |
| AuthorAffiliation | 1 Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA 3 Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA 2 Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA |
| AuthorAffiliation_xml | – name: 2 Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA – name: 3 Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA – name: 1 Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA |
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| Cites_doi | 10.1021/bi00437a001 10.1016/j.molcel.2018.06.039 10.1016/j.bbabio.2010.03.006 10.1073/pnas.53.2.410 10.1038/nature20117 10.1074/jbc.R800068200 10.7554/eLife.17828 10.1016/j.bbalip.2016.08.011 |
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| Keywords | acetyl-coA acyl-carrier protein (ACP) fatty acid synthesis mitochondria nutrient sensing |
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| References | Kastaniotis (bib0025) 2017; 1862 Van Vranken (bib0030) 2016; 5 Hiltunen (bib0015) 2010; 1797 Baytaktar (bib0035) 2018 Wakil (bib0040) 1989; 28 Dulbecco (bib0020) 1965; 53 Van Vranken (bib0005) 2018; 71 Hiltunen (bib0010) 2009; 284 Wei (bib0045) 2016; 539 Wei (10.1016/j.tem.2018.10.003_bib0045) 2016; 539 Kastaniotis (10.1016/j.tem.2018.10.003_bib0025) 2017; 1862 Hiltunen (10.1016/j.tem.2018.10.003_bib0010) 2009; 284 Baytaktar (10.1016/j.tem.2018.10.003_bib0035) 2018 Van Vranken (10.1016/j.tem.2018.10.003_bib0005) 2018; 71 Van Vranken (10.1016/j.tem.2018.10.003_bib0030) 2016; 5 Hiltunen (10.1016/j.tem.2018.10.003_bib0015) 2010; 1797 Wakil (10.1016/j.tem.2018.10.003_bib0040) 1989; 28 Dulbecco (10.1016/j.tem.2018.10.003_bib0020) 1965; 53 |
| References_xml | – year: 2018 ident: bib0035 article-title: MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types publication-title: BioRxiv contributor: fullname: Baytaktar – volume: 71 start-page: 567 year: 2018 end-page: 580 ident: bib0005 article-title: ACP acylation is an acetyl-CoA-dependent modification required for electron transport chain assembly publication-title: Mol. Cell contributor: fullname: Van Vranken – volume: 539 start-page: 294 year: 2016 end-page: 298 ident: bib0045 article-title: Fatty acid synthesis configures the plasma membrane for inflammation in diabetes publication-title: Nature contributor: fullname: Wei – volume: 53 start-page: 410 year: 1965 end-page: –417 ident: bib0020 article-title: Acyl carrier protein. IV. The identification of 4′-phosphopantetheine as the prosthetic group of the acyl carrier protein publication-title: Proc. Natl. Acad. Sci. contributor: fullname: Dulbecco – volume: 28 start-page: 4523 year: 1989 end-page: 4530 ident: bib0040 article-title: Fatty acid synthase, a proficient multifunctional enzyme publication-title: Biochemistry contributor: fullname: Wakil – volume: 1797 start-page: 1195 year: 2010 end-page: 1202 ident: bib0015 article-title: Mitochondrial fatty acid synthesis and respiration publication-title: Biochim. Biophys. Acta contributor: fullname: Hiltunen – volume: 1862 start-page: 39 year: 2017 end-page: 48 ident: bib0025 article-title: Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology publication-title: Biochim. Biophys. Acta Mol. Cell Biol. Lipids contributor: fullname: Kastaniotis – volume: 5 year: 2016 ident: bib0030 article-title: The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis publication-title: eLife contributor: fullname: Van Vranken – volume: 284 start-page: 9011 year: 2009 end-page: 9015 ident: bib0010 article-title: Mitochondrial fatty acid synthesis type II: more than just fatty acids publication-title: J. Biol. Chem. contributor: fullname: Hiltunen – volume: 28 start-page: 4523 year: 1989 ident: 10.1016/j.tem.2018.10.003_bib0040 article-title: Fatty acid synthase, a proficient multifunctional enzyme publication-title: Biochemistry doi: 10.1021/bi00437a001 contributor: fullname: Wakil – volume: 71 start-page: 567 year: 2018 ident: 10.1016/j.tem.2018.10.003_bib0005 article-title: ACP acylation is an acetyl-CoA-dependent modification required for electron transport chain assembly publication-title: Mol. Cell doi: 10.1016/j.molcel.2018.06.039 contributor: fullname: Van Vranken – volume: 1797 start-page: 1195 year: 2010 ident: 10.1016/j.tem.2018.10.003_bib0015 article-title: Mitochondrial fatty acid synthesis and respiration publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbabio.2010.03.006 contributor: fullname: Hiltunen – year: 2018 ident: 10.1016/j.tem.2018.10.003_bib0035 article-title: MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types publication-title: BioRxiv contributor: fullname: Baytaktar – volume: 53 start-page: 410 year: 1965 ident: 10.1016/j.tem.2018.10.003_bib0020 article-title: Acyl carrier protein. IV. The identification of 4′-phosphopantetheine as the prosthetic group of the acyl carrier protein publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.53.2.410 contributor: fullname: Dulbecco – volume: 539 start-page: 294 year: 2016 ident: 10.1016/j.tem.2018.10.003_bib0045 article-title: Fatty acid synthesis configures the plasma membrane for inflammation in diabetes publication-title: Nature doi: 10.1038/nature20117 contributor: fullname: Wei – volume: 284 start-page: 9011 year: 2009 ident: 10.1016/j.tem.2018.10.003_bib0010 article-title: Mitochondrial fatty acid synthesis type II: more than just fatty acids publication-title: J. Biol. Chem. doi: 10.1074/jbc.R800068200 contributor: fullname: Hiltunen – volume: 5 year: 2016 ident: 10.1016/j.tem.2018.10.003_bib0030 article-title: The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis publication-title: eLife doi: 10.7554/eLife.17828 contributor: fullname: Van Vranken – volume: 1862 start-page: 39 year: 2017 ident: 10.1016/j.tem.2018.10.003_bib0025 article-title: Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology publication-title: Biochim. Biophys. Acta Mol. Cell Biol. Lipids doi: 10.1016/j.bbalip.2016.08.011 contributor: fullname: Kastaniotis |
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| Snippet | Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell... Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al . [ 1 ] ( Mol. Cell... |
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| SubjectTerms | Acetyl Coenzyme A - metabolism acetyl-coA Acyl Carrier Protein - metabolism acyl-carrier protein (ACP) Eukaryota - metabolism fatty acid synthesis Fatty Acids - metabolism mitochondria Mitochondria - metabolism nutrient sensing Respiration |
| Title | Sensing Mitochondrial Acetyl-CoA to Tune Respiration |
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