Sensing Mitochondrial Acetyl-CoA to Tune Respiration

Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for...

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Bibliographic Details
Published inTrends in endocrinology and metabolism Vol. 30; no. 1; pp. 1 - 3
Main Authors Mills, Christine A., Trub, Alec G., Hirschey, Matthew D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.01.2019
Subjects
Acetyl Coenzyme A - metabolism
acetyl-coA
Acyl Carrier Protein - metabolism
acyl-carrier protein (ACP)
Eukaryota - metabolism
fatty acid synthesis
Fatty Acids - metabolism
mitochondria
Mitochondria - metabolism
nutrient sensing
Respiration
acetyl-coA
acyl-carrier protein (ACP)
fatty acid synthesis
mitochondria
nutrient sensing
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Summary:Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2018.10.003