Association of non-HDL-C/HDL-C ratio and its dynamic changes with incident type 2 diabetes mellitus: The Rural Chinese Cohort Study

• Published in: Journal of diabetes and its complications Vol. 34; no. 12; p. 107712
• Main Authors: Han, Minghui, Li, Quanman, Qie, Ranran, Guo, Chunmei, Zhou, Qionggui, Tian, Gang, Huang, Shengbing, Wu, Xiaoyan, Ren, Yongcheng, Zhao, Yang, Liu, Dechen, Zhang, Dongdong, Liu, Leilei, Liu, Feiyan, Chen, Xu, Cheng, Cheng, Li, Yang, Yang, Xingjin, Feng, Yifei, Liu, Yu, Li, Honghui, Sun, Xizhuo, Qin, Pei, Chen, Qing, Zhang, Ming, Hu, Dongsheng, Lu, Jie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020; Elsevier Limited
• Subjects: Age; Alcohol; Alzheimer's disease; Body mass index; Cardiovascular disease; Cholesterol; Cohort analysis; Diabetes; Dynamic change; Family medical history; Laboratories; Lipids; Marital status; Non-HDL-C/HDL-C ratio; Prospective cohort study; Public health; Questionnaires; Rural areas; Smoking; Type 2 diabetes mellitus; China; Non-HDL-C/HDL-C ratio; Type 2 diabetes mellitus; Dynamic change; Prospective cohort study
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2020.107712

We aimed to evaluate the association of the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) and its dynamic changes with incident type 2 diabetes mellitus (T2DM). A total of 11,487 nondiabetic participants ≥18 years old in rural China were recruited in 2007–2008 and followed up in 2013–2014. A Cox proportional-hazards model was used to assess the risk of incident T2DM by quartiles of baseline non-HDL-C/HDL-C ratio and dynamic absolute and relative changes in non-HDL-C/HDL-C ratio, estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Risk of incident T2DM was increased with quartiles 2, 3, and 4 versus quartile 1 of baseline non-HDL-C/HDL-C ratio (HR 1.46 [95% CI 1.08–1.98], 1.51 [1.12–2.03], and 2.16 [1.62–2.88], Ptrend < 0.001). As compared with stable non-HDL-C/HDL-C ratio during follow-up, an absolute gain in non-HDL-C/HDL-C ratio was associated with increased risk of T2DM (HR 1.67 [95% CI 1.25–2.24] for quartile 3 and 2.00 [1.52–2.61] for quartile 4). A relative increase in non-HDL-C/HDL-C ratio was also associated with increased risk of T2DM (HR 1.56 [95% CI 1.19–2.04] for quartile 3 and 1.97 [1.49–2.60] for quartile 4). Subgroup analyses showed that the association of non-HDL-C/HDL-C ratio with T2DM risk remained consistent. Increased non-HDL-C/HDL-C ratio is associated with increased risk of incident T2DM among rural Chinese adults, so the index may be an important indicator for identifying individuals at T2DM risk. •Our study explored non-HDL-C/HDL-C as a novel indicator for identifying subjects at T2DM risk based on large simple size.•We found a positive association of baseline non-HDL-C/HDL-C and its dynamic gains during follow-up with risk of T2DM.•Monitoring and reducing non-HDL-C/HDL-C ratio may be helpful to prevent and control incident T2DM.