Anti-oxidative stress properties by Lactiplantibacillus plantarum SCS3 in streptozotocin-induced diabetic mice

• Published in: CYTA: journal of food Vol. 20; no. 1; pp. 297 - 304
• Main Authors: Meng, Xiao, Liu, Shukun, Liu, Qiuyan, Zhang, Ying, Jing, Lin, Huang, Xinyi, Sun, Jiayi, Ye, Lu
• Format: Journal Article
• Language: English; Spanish
• Published: Abingdon Taylor & Francis 31.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Antioxidants; Bacteria; Catalase; Chinese medicine; Deoxyribonucleic acid; Diabetes; Diabetes mellitus; diabetes tipo 2; DNA; ensayo inmunoabsorbente ligado a enzimas; Enzyme-linked immunosorbent assay; Enzymes; experimental techniques; Free radicals; Glutathione; Hemoglobin; Hyperglycemia; improvement; Insulin; Intracellular; Lactiplantibacillus plantarum; Lactiplantibacillus plantarum SCS; Lactiplantibacillus plantarum SCS3; Medical research; mejora en el estrés oxidativo; Oxidative stress; Pharmacy; Reactive oxygen species; Streptozocin; Superoxide dismutase; type 2 diabetes; técnicas experimentales; Weight loss
• ISSN: 1947-6337; 1947-6345
• DOI: 10.1080/19476337.2022.2136759

This study investigated the ability of Lactiplantibacillus plantarum SCS3 (L. plantarum SCS3) to alleviate oxidative stress in diabetic mice. Diabetic mouse model was established by administering 50 mg/kg (bodyweight) of streptozocin for 5 days. We then applied 0.5 mL of 1.0 × 10 10 CFU/mL L. plantarum SCS3 cell suspension (TGa group), its intracellular contents (TGb group), or boiled intracellular contents (TGc group) to mice for ten weeks. Compared with the model group (MG), weight loss and hyperglycemia were most effectively ameliorated in the TGc group compared to the other treatment groups; based on the enzyme linked immunosorbent assay, levels of insulin and glycosylated hemoglobin were improved; the reactive oxygen species level decreased, while superoxide dismutase, catalase, and glutathione levels in the TGc mice increased significantly (P < .05). In conclusion, the boiled intracellular contents of L. plantarum SCS3 regulated oxidative stress and improved diabetes-related indicators in diabetic mice.