Hypogonadotropic hypogonadism in men with hereditary hemochromatosis

Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and...

Full description

Saved in:
Bibliographic Details
Published inBasic and clinical andrology Vol. 27; no. 1; p. 13
Main Authors El Osta, Rabih, Grandpre, Nicolas, Monnin, Nicolas, Hubert, Jacques, Koscinski, Isabelle
Format Journal Article
LanguageEnglish
Published England BioMed Central 08.07.2017
Subjects
Binding sites
Erectile dysfunction
Fertility
Homeostasis
Infertility
Iron
Metabolism
Patients
Physiology
Proteins
Review
Rodents
Spermatogenesis
Hypogonadotropic Hypogonadism
Male infertility
Hereditary Hemochromatosis
Online AccessGet full text

Cover

More Information
Summary:Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities. This review is based on an online search in English, French and German language publications found in PubMed/Medline, up to 23 September 2016 using the following key word: Male infertility, Hypogonadotropic Hypogonadism, Hereditary Hemochromatosis. Thirty-four papers met these inclusion criteria. This review describes the impact of iron overload on male fertility, resulting in hypogonadotropic hypogonadism and proposes treatment modalities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2051-4190
2051-4190
DOI:10.1186/s12610-017-0057-8