Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

• Published in: Bioorganic & medicinal chemistry letters Vol. 19; no. 5; pp. 1481 - 1483
• Main Authors: Ahn, Chan Mug, Park, Byong-Gon, Woo, Ho Bum, Ham, Jungyeob, Shin, Woon-Seob, Lee, Seokjoon
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2009
• Subjects: Animals; Basilar artery; Basilar Artery - drug effects; Basilar Artery - physiology; Curcumin; Curcumin - chemical synthesis; Curcumin - pharmacology; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Molecular Mimicry - physiology; Organic synthesis; Rabbits; Sulfinic Acids - chemical synthesis; Sulfinic Acids - pharmacology; Sulfonyl curcumin mimics; Vasodilatation; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - chemical synthesis; Vasodilator Agents - pharmacology; Organic synthesis; Vasodilatation; Sulfonyl curcumin mimics; Basilar artery; Curcumin
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2009.01.019

In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type ( 3) and sulfonyl amide type ( 4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic ( 4) is more potent than the amide type ( 3). Curcumin ( 1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits.