Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology—Thirty Years of Progress but Still Much to Be Done

Although rare, Stevens-Johnson syndrome and toxic epidermal necrolysis remain among the most devastating of acute conditions involving the skin. In the past 30 years, tremendous progress has been made in understanding the causes and pathobiology of this often life-threatening condition. Su et al dem...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 137; no. 5; pp. 1004 - 1008
Main Authors Stern, Robert S., Divito, Sherrie J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2017
Subjects
Acute Disease
Cytokines
Humans
Interleukin-15
Skin
Stevens-Johnson Syndrome
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Summary:Although rare, Stevens-Johnson syndrome and toxic epidermal necrolysis remain among the most devastating of acute conditions involving the skin. In the past 30 years, tremendous progress has been made in understanding the causes and pathobiology of this often life-threatening condition. Su et al demonstrate associations between IL 15 serum levels and the outcome of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. Their findings provide ideas for further investigations that may help us better understand the role of cytokines in this T-cell mediate disease and provides clues to possible new therapies.
ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2017.01.003