Opsin3—A Link to Visible Light-Induced Skin Pigmentation

Skin pigmentation is primarily dependent on melanogenesis, a physiological process that occurs in melanosomes of melanocytes. Solar radiation modulates pigmentation through variety of signaling pathways, but the mechanism of visible light-induced hyperpigmentation remains uncharacterized. Passeron’s...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 138; no. 1; pp. 13 - 15
Main Author Setty, Subba Rao
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2018
Subjects
Melanins
Melanocytes
Microphthalmia-Associated Transcription Factor - genetics
Opsins
Skin Pigmentation
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Summary:Skin pigmentation is primarily dependent on melanogenesis, a physiological process that occurs in melanosomes of melanocytes. Solar radiation modulates pigmentation through variety of signaling pathways, but the mechanism of visible light-induced hyperpigmentation remains uncharacterized. Passeron’s group recently reported that visible light stimulates opsin3-regulated calcium-dependent microphthalmia-associated transcription factor activation that increases pigment gene expression and that it also causes the clustering of melanogenic enzymes. Together, these processes possibly contribute to long-lasting hyperpigmentation in the melanocompetent skins.
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ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2017.09.025