Serum Survivin in Oral Submucosal Fibrosis and Squamous Cell Carcinoma

• Published in: Indian journal of otolaryngology, and head, and neck surgery Vol. 74; no. Suppl 2; pp. 2027 - 2032
• Main Authors: Thota, Ramya, Aggarwal, Sadhna, Chirom, Amit Singh, Thakar, Alok, Gupta, Siddhartha Dutta, Sharma, Suresh C., Das, Satya N.
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.10.2022; Springer Nature B.V
• Subjects: Apoptosis; Biomarkers; Head and Neck Surgery; Medicine; Medicine & Public Health; Oral cancer; Original; Original Article; Otorhinolaryngology; Squamous cell carcinoma; OSMF; OSCC; Biomarker; Survivin; ELISA
• ISSN: 2231-3796; 0973-7707
• DOI: 10.1007/s12070-020-01980-0

Survivin, an inhibitor of apoptosis protein is a biomarker of significance in prognostication of many malignancies. In the current study we investigated the serum survivin levels in patients with oral submucosal fibrosis (OSMF) and squamous cell carcinoma (OSCC). Serum was isolated from, peripheral blood collected of clinically and histopathologically confirmed OSMF and OSCC patients. Circulating level of survivin was measured in patients and control subjects by ELISA and analyzed further using Kruskal–Wallis test and two-sample Wilcoxon rank-sum (Mann–Whitney) test. Serum Survivin levels were significantly reduced in the OSCC group as compared to the control group. No significant correlation was noted between the serum survivin level and various clinicopathological characteristics of OSCC and OSMF patients. Our study suggests that free, wild form of circulating survivin probably has no role in predicting the prognosis of oral cancer or the malignant transformation potential of oral submucosal fibrosis.