Inhibition of histone deacetylase1 induces autophagy

• Published in: Biochemical and biophysical research communications Vol. 369; no. 4; pp. 1179 - 1183
• Main Authors: Oh, Meeyeon, Choi, In-Kwon, Kwon, Ho Jeong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.05.2008
• Subjects: Animals; Antibiotics, Antineoplastic - pharmacology; Autophagy; Autophagy - drug effects; Autophagy - genetics; Depsipeptides - pharmacology; Enzyme Inhibitors - pharmacology; FK228; HeLa Cells; Histone Deacetylase 1; Histone deacetylase inhibitor; Histone Deacetylase Inhibitors; Histone deacetylase1; Histone Deacetylases - genetics; Humans; Microtubule-Associated Proteins - metabolism; RNA, Small Interfering - pharmacology; Histone deacetylase1; Histone deacetylase inhibitor; Autophagy; FK228

Autophagy is a process where cytoplasmic materials are degraded by lysosomal machinery. Histone deacetylase (HDAC) inhibitors induce autophagy, and HDAC6, one of class II HDAC isotypes, is directly involved in autophagic degradation in the cell. However, it is unclear if class I HDAC isotype such as...