Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

• Published in: Inflammation research Vol. 71; no. 7-8; pp. 817 - 831
• Main Authors: Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2022; Springer Nature B.V
• Subjects: Aging; Allergology; Biomedical and Life Sciences; Biomedicine; Contact dermatitis; Degeneration; Dendritic cells; Dermatology; Effector cells; Hypersensitivity; Immune system; Immunology; Immunoregulation; Immunosenescence; Immunosuppression; Immunosuppressive agents; Inflammation; Lymphocytes; Lymphocytes T; Molecular modelling; Neurology; Pharmacology/Toxicology; Radiation effects; Review; Rheumatology; Senescence; Skin; Suppressor cells; Ultraviolet radiation; UVB; Aging; UVA; Anti-inflammatory; Carcinogenesis; Lifespan

Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging. Over 30 years ago, it was observed that UVR induced an immunosuppressive state which inhibited skin contact hypers...