Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

• Published in: Inflammation research Vol. 71; no. 7-8; pp. 817 - 831
• Main Authors: Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2022; Springer Nature B.V
• Subjects: Aging; Allergology; Biomedical and Life Sciences; Biomedicine; Contact dermatitis; Degeneration; Dendritic cells; Dermatology; Effector cells; Hypersensitivity; Immune system; Immunology; Immunoregulation; Immunosenescence; Immunosuppression; Immunosuppressive agents; Inflammation; Lymphocytes; Lymphocytes T; Molecular modelling; Neurology; Pharmacology/Toxicology; Radiation effects; Review; Rheumatology; Senescence; Skin; Suppressor cells; Ultraviolet radiation; UVB; Aging; UVA; Anti-inflammatory; Carcinogenesis; Lifespan
• ISSN: 1023-3830; 1420-908X; 1420-908X
• DOI: 10.1007/s00011-022-01598-8

Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging. Over 30 years ago, it was observed that UVR induced an immunosuppressive state which inhibited skin contact hypersensitivity. Methods Original and review articles encompassing inflammation and immunosuppression in the photoaging and chronological aging processes were examined from major databases including PubMed, Scopus, and Google Scholar. Results Currently it is known that UVR treatment can trigger a cellular senescence and inflammatory state in the skin. Chronic low-grade inflammation stimulates a counteracting immunosuppression involving an expansion of immunosuppressive cells, e.g., regulatory T cells (Treg), myeloid-derived suppressor cells (MDSC), and regulatory dendritic cells (DCreg). This increased immunosuppressive activity not only suppresses the function of effector immune cells, a state called immunosenescence, but it also induces bystander degeneration of neighboring cells. Interestingly, the chronological aging process also involves an accumulation of pro-inflammatory senescent cells and signs of chronic low-grade inflammation, called inflammaging. There is also clear evidence that inflammaging is associated with an increase in anti-inflammatory and immunosuppressive activities which promote immunosenescence. Conclusion It seems that photoaging and normal aging evoke similar processes driven by the remodeling of the immune system. However, it is likely that there are different molecular mechanisms inducing inflammation and immunosuppression in the accelerated photoaging and the chronological aging processes.