Quantity of clonal cells detected by conventional cytogenetic analysis correlates with bone marrow blasts and survival in myelodysplastic syndromes

• Published in: Leukemia research Vol. 36; no. 2; pp. 163 - 168
• Main Authors: Kim, Miyoung, Chung, Soie, See, Cha Ja, Yoon, Sung-Soo, Kim, Byoung Kook, Kim, Hyun Kyung, Lee, Dong Soon
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2012
• Subjects: Adult; Aged; Aged, 80 and over; Blast Crisis; Bone Marrow - pathology; Chromosome Aberrations; Clonality; Clone Cells; Conventional cytogenetic analysis; Cytogenetic Analysis; Female; FISH; Hematology, Oncology and Palliative Medicine; Humans; In Situ Hybridization, Fluorescence; Interphase; Karyotyping; Male; MDS; Middle Aged; Myelodysplastic Syndromes - genetics; Myelodysplastic Syndromes - mortality; Myelodysplastic Syndromes - pathology; Prognosis; Quantity; Survival Rate; Young Adult; FISH; Clonality; Quantity; Conventional cytogenetic analysis; MDS
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2011.08.021

Abstract We performed quantitative and qualitative analyses of conventional cytogenetic analysis and interphase FISH results in 87 MDS patients. The quantity of clonal cells for each chromosome of CCA did not correlate with the result of iFISH ( r , range 0.0761–1.0577). The clonal cell percentage in CCA was higher in patients with >5% bone marrow blasts than those with <5% (44.7% vs. 23.1%, p = 0.017). Multivariate analysis showed that a high quantity of clonal cells in CCA analysis is an independent prognostic factor for overall survival in MDS ( p = 0.012).