Mechanisms of Organ Dysfunction in Sepsis

Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. The effect of targeting these mechanistic pathways on short- and long-term outcomes depends...

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Bibliographic Details
Published inCritical care clinics Vol. 34; no. 1; p. 63
Main Authors Pool, Rachel, Gomez, Hernando, Kellum, John A
Format Journal Article
LanguageEnglish
Published United States 01.01.2018
Subjects
Humans
Multiple Organ Failure - immunology
Multiple Organ Failure - physiopathology
Sepsis - immunology
Sepsis - physiopathology
Microcirculation
Sepsis
Mitochondria
Inflammation
Organ dysfunction
Metabolism
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Summary:Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. The effect of targeting these mechanistic pathways on short- and long-term outcomes depends highly on the timing of therapeutic intervention. Furthermore, there is a need to understand the adaptive or maladaptive character of these mechanisms, to discover phase-specific biomarkers to guide therapy, and to conceptualize these mechanisms in terms of resistance and tolerance.
ISSN:1557-8232
DOI:10.1016/j.ccc.2017.08.003