Association of FTO, ABCA1, ADRB3, and PPARG variants with obesity, type 2 diabetes, and metabolic syndrome in a Northwest Mexican adult population

• Published in: Journal of diabetes and its complications Vol. 35; no. 11; p. 108025
• Main Authors: Velazquez-Roman, Jorge, Angulo-Zamudio, Uriel A., León-Sicairos, Nidia, Medina-Serrano, Julio, DeLira-Bustillos, Nora, Villamil-Ramírez, Hugo, Canizales-Quinteros, Samuel, Macías-Kauffer, Luis, Campos-Romero, Abraham, Alcántar-Fernández, Jonathan, Canizalez-Roman, Adrian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2021; Elsevier Limited
• Subjects: ABCA; ADRB3 and PPARG; Adult; Adults; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; ATP Binding Cassette Transporter 1; Blood pressure; Body mass index; Cholesterol; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; FTO; Genetic Predisposition to Disease; Genotype; Glucose; Health risk assessment; Humans; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - epidemiology; Metabolic Syndrome - genetics; Mexico - epidemiology; Obesity; Obesity - complications; Obesity - genetics; Overweight; Polymorphism, Single Nucleotide; Population; PPAR gamma - genetics; Receptors, Adrenergic, beta-3 - genetics; SNP; Triglycerides; Type 2 diabetes; Mexico; United States > US; FTO; Type 2 diabetes; ABCA; Obesity; SNP; ADRB3 and PPARG; Metabolic syndrome
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2021.108025

To identify associations among allelic variants of the genes FTO, ABCA1, ADRB3, and PPARG with anthropometric and biochemical traits, metabolic diseases (obesity, T2D or metabolic syndrome) in an adult population from Northwest Mexico. Blood samples were collected from 846 subjects including 266 normal weight subjects, 285 with obesity, and 295 with T2D. Of the 846 persons in the study, 365 presented metabolic syndrome diagnostic criteria. Anthropometric and biochemical traits were recorded and 4 single nucleotide polymorphisms (SNPs): FTO rs9939609 A-allele, ABCA1 rs9282541 A-allele, ADRB3 rs4994 G-allele, and PPARG rs1801282 G-allele were genotyped by real-time PCR. FTO rs9939609 A-allele was significantly associated with obesity (p: 8.3 × 10−4), and metabolic syndrome (p: 0.001), but no individual SNPs were significantly associated with T2D. Finally, the cumulative risk of the four SNPs was significantly associated with obesity (p: 1.95 × 10−4). Associations in FTO, ABCA, ADRB3, and PPARG SNPs presented in this study with obesity and metabolic syndrome could represent a risk for developing metabolic diseases in Northwest Mexican adult subjects. •FTO rs9939609 A-allele, ABCA1 rs9282541 A-allele, and PPARG rs1801282 G-allele were related with changes in anthropometrical in a Northwest Mexican adult population.•FTO rs9939609 A-allele was associated with obesity and metabolic syndrome.•PPARG rs1801282 G-allele was associated with obesity.•The cumulative risk of the four SNPs was associated with obesity, T2D, and metabolic syndrome