Review of the Potential Therapeutic Effects and Molecular Mechanisms of Resveratrol on Endometriosis

Endometriosis is a hormone-dependent inflammatory disease characterized by the existence of endometrial tissues outside the uterine cavity. Pharmacotherapy and surgery are the current dominant management options for endometriosis. The greater incidence of recurrence and reoperation after surgical tr...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of women's health Vol. 15; pp. 741 - 763
Main Authors Jiang, Tao, Chen, Yuan, Gu, Xia, Miao, Mengyue, Hu, Daifeng, Zhou, Hui, Chen, Jing, Teichmann, Alexander Tobias, Yang, Youzhe
Format Journal Article
LanguageEnglish
Published New Zealand Dove 01.01.2023
Dove Medical Press
Subjects
clinical application
endometriosis
molecular mechanisms
resveratrol
Review
therapeutic efficacies
endometriosis
therapeutic efficacies
clinical application
molecular mechanisms
resveratrol
Online AccessGet full text

Cover

More Information
Summary:Endometriosis is a hormone-dependent inflammatory disease characterized by the existence of endometrial tissues outside the uterine cavity. Pharmacotherapy and surgery are the current dominant management options for endometriosis. The greater incidence of recurrence and reoperation after surgical treatment as well as the adverse effects of medical approaches predispose patients to potential limitations for their long-term usage. Consequently, it is essential to explore novel supplementary and alternative drugs to ameliorate the therapeutic outcomes of endometriotic patients. Resveratrol is a phenolic compound that has attracted increasing interest from many researchers due to its pleiotropic biological activities. Here, we review the possible therapeutic efficacies and molecular mechanisms of resveratrol against endometriosis based on in vitro, animal, and clinical studies. The potential mechanisms of resveratrol include anti-proliferative, pro-apoptotic, anti-angiogenic, anti-oxidative stress, anti-invasive and anti-adhesive effects, thereby suggesting that resveratrol is a promising candidate for endometriosis. Because most studies have investigated the effectiveness of resveratrol on endometriosis via in vitro trials and/or experimental animal models, further high-quality clinical trials should be undertaken to comprehensively estimate the clinical application feasibility of resveratrol on endometriosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work
ISSN:1179-1411
1179-1411
DOI:10.2147/IJWH.S404660