Intrauterine Growth and Neuropsychological Performance in Very Low Birth Weight Preschoolers

• Published in: Journal of the International Neuropsychological Society Vol. 18; no. 2; pp. 200 - 211
• Main Authors: Raz, Sarah, DeBastos, Angela K., Newman, Julie Bapp, Batton, Daniel
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.03.2012
• Subjects: Birth weight; Child; Child, Preschool; Cognition Disorders - diagnosis; Female; Fetal Growth Retardation - physiopathology; Gestational Age; Humans; Hypertension; Infant, Newborn; Infant, Very Low Birth Weight; Male; Middle class; Neuropsychological Tests; Neuropsychology; Newborn babies; Premature birth; Retrospective Studies; Surfactants; Young adults; Intelligence tests; Language tests; Intrauterine growth retardation; Preterm birth; Preschool children; Motor skills
• ISSN: 1355-6177; 1469-7661
• DOI: 10.1017/S1355617711001767

In this study we examined the association between intrauterine growth, indexed either as a categorical variable or continuous dimension, and neuropsychological outcome, in a very low birth weight (VLBW) sample of 143 preschoolers. When the commonly used split at the 10th percentile rank was applied to classify intrauterine growth restriction (IUGR), we found that the growth restricted group (n = 25) exhibited significantly poorer performance in the global motor domain, but not on any other neuropsychological measure. In contrast, when adequacy of intrauterine growth was indexed by standardized birth weight, a continuous dimension, this early risk factor explained a unique portion of the variance in global cognitive abilities and visuospatial skills, as well as in global, fine, and gross motor skills. These findings are consistent with recent magnetic resonance imaging data disclosing global neurodevelopmental changes in the brains of preterm infants with IUGR. When cases classified with IUGR (<10th percentile) were excluded, the relationship between adequacy of intrauterine growth and global cognitive abilities remained significant despite range restriction. Hence, an association between appropriateness of intrauterine growth and global intellectual outcome may be observed even within the population of VLBW preschoolers with adequate standardized birth weight. (JINS, 2012, 18, 200–211)